Spectral editing with adiabatic pulses

J Magn Reson B. 1995 Nov;109(2):184-93. doi: 10.1006/jmrb.1995.0008.

Abstract

Amplitude- and frequency-modulated pulses, known as adiabatic pulses, can induce uniform flip angles in the presence of extreme B1 inhomogeneity, which makes them advantageous for in vivo surface-coil studies. This paper describes the conversion of conventional (square pulse-based) spectral-editing sequences into their adiabatic counterparts. Eight adiabatic homo- and heteronuclear sequences are experimentally evaluated for lactate editing. For homonuclear lactate editing, gradient-enhanced multiple-quantum-coherence filtering provides the best overall performance (100% signal recovery with excellent water and lipid suppression in a single acquisition). For heteronuclear [3-(13)C]lactate editing, gradient-enhanced heteronuclear multiple-quantum-coherence filtering provides the best suppression of unwanted signals in a single acquisition, whereas J-modulated spin-echo sequences yield maximum sensitivity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Brain Neoplasms / metabolism
  • Carbon Isotopes
  • Choline / analysis
  • Creatine / analysis
  • Feasibility Studies
  • Glioma / metabolism
  • Lactates / analysis
  • Lactates / metabolism
  • Lipids
  • Magnetic Resonance Spectroscopy / methods*
  • Models, Structural
  • Rats
  • Signal Processing, Computer-Assisted
  • Water

Substances

  • Carbon Isotopes
  • Lactates
  • Lipids
  • Water
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline