Thrombin active site inhibitors

Bioorg Med Chem. 1995 Aug;3(8):999-1007. doi: 10.1016/0968-0896(95)00104-o.

Abstract

Development of small molecule thrombin active site inhibitors has been an area of intense research. A brief review on recent progress and challenges is outlined.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Anticoagulants / chemistry*
  • Anticoagulants / pharmacology
  • Antithrombins / chemistry*
  • Antithrombins / pharmacology
  • Binding Sites
  • Drug Design
  • Humans
  • Molecular Structure
  • Serine
  • Structure-Activity Relationship
  • Thrombin / antagonists & inhibitors*
  • Thrombin / chemistry*

Substances

  • Anticoagulants
  • Antithrombins
  • Serine
  • Thrombin