Abstract
Development of small molecule thrombin active site inhibitors has been an area of intense research. A brief review on recent progress and challenges is outlined.
MeSH terms
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Anticoagulants / chemistry*
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Anticoagulants / pharmacology
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Antithrombins / chemistry*
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Antithrombins / pharmacology
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Binding Sites
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Drug Design
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Humans
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Molecular Structure
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Serine
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Structure-Activity Relationship
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Thrombin / antagonists & inhibitors*
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Thrombin / chemistry*
Substances
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Anticoagulants
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Antithrombins
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Serine
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Thrombin