The authors report their own results of local immunomodulation with IRS 19 in 57 atopic and nonatopic children having nonspecific chronical diseases of the respiratory tract. The results were obtained on the basis of complex diagnostical procedures before and after local immunomodulation. These results are demonstrated by tables, figures and graphs. By comparing the results obtained with local immunomodulation, it was found that prophylactic and therapeutic efficiency of IRS 19 is better in nonatopic children than in atopic ones. The detailed analyses showed that the local immunomodulation caused not only an increased concentration of the immunoglobulins IgG, IgM, IgA but also of the IgE.