Abstract
Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Breast Neoplasms / genetics
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Carcinoma, Hepatocellular / genetics
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Carcinoma, Renal Cell / blood
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Carcinoma, Renal Cell / epidemiology
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Carcinoma, Renal Cell / genetics*
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Europe / epidemiology
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Exons
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Female
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Genes, Tumor Suppressor*
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Humans
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Kidney Neoplasms / blood
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Kidney Neoplasms / epidemiology
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Kidney Neoplasms / genetics*
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Liver Neoplasms / genetics
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Lymphocytes / chemistry
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation*
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Polymorphism, Single-Stranded Conformational
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Tumor Cells, Cultured
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von Hippel-Lindau Disease / genetics*