Four cases of glandular odontogenic cyst are reported. Review of these and 13 previously reported cases indicates that they present as slowly growing, painless, radiolucent swellings with a predilection for the anterior part of the mandible. An incisional biopsy is essential to establish a definitive preoperative diagnosis. The unpredictable and potentially aggressive nature of these lesions is suggested by their extensive nature, penetration of cortical bone, locally invasive potential, and high incidence of recurrence after conservative treatment. In view of this behavior we suggest en bloc excision and primary reconstruction to ensure cure and reduce the operative morbidity.