Epstein-Barr virus lymphoproliferative disease of donor origin after kidney transplantation: a case report

E Renoult; B Aymard; M J Grégoire; A Bellou; J Hubert; D Hestin; J Audouin; P Lederlin; M Kessler

doi:10.1016/0272-6386(95)90159-0

Epstein-Barr virus lymphoproliferative disease of donor origin after kidney transplantation: a case report

Am J Kidney Dis. 1995 Jul;26(1):84-7. doi: 10.1016/0272-6386(95)90159-0.

Authors

E Renoult¹, B Aymard, M J Grégoire, A Bellou, J Hubert, D Hestin, J Audouin, P Lederlin, M Kessler

Affiliation

¹ Division of Nephrology, Hôpital de Brabois, University of Nancy, France.

PMID: 7611274
DOI: 10.1016/0272-6386(95)90159-0

Abstract

A case of an Epstein-Barr virus (EBV)-associated B lymphoproliferative disorder presented as a renal transplant obstruction is reported. The diagnosis was made from histology, immunohistochemistry, and EBV expression studies. Cytogenetic analysis showed the tumor to be of donor origin and revealed chromosomal translocation 46, XY, inv (1)(p35; q41), involving the EBV insertion site 1(1p35) and transforming growth factor beta 2(1q41) loci.

Publication types

Case Reports

MeSH terms

Aged
B-Lymphocytes
Chromosome Inversion
Chromosomes, Human, Pair 1
DNA Transposable Elements / genetics
DNA, Viral / genetics
Female
Herpesviridae Infections / genetics
Herpesviridae Infections / transmission*
Herpesviridae Infections / virology
Herpesvirus 4, Human* / genetics
Humans
Kidney Transplantation / adverse effects*
Lymphoproliferative Disorders / etiology*
Lymphoproliferative Disorders / genetics
Lymphoproliferative Disorders / virology
Tissue Donors*
Transforming Growth Factor beta / genetics
Tumor Virus Infections / genetics
Tumor Virus Infections / transmission*
Tumor Virus Infections / virology

Substances

DNA Transposable Elements
DNA, Viral
Transforming Growth Factor beta