Objective: To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
Subjects and methods: The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo.
Results: Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin.
Conclusions: The urinary side-effects of khat chewing are probably mediated through stimulation of alpha 1-adrenergic receptors.