Interspecific complementation between mouse and Chinese hamster cell mutants hypersensitive to ionizing radiation

K Sato; D J Chen; K Eguchi-Kasai; H Itsukaichi; T Odaka; G F Strniste

doi:10.1269/jrr.36.38

Interspecific complementation between mouse and Chinese hamster cell mutants hypersensitive to ionizing radiation

J Radiat Res. 1995 Mar;36(1):38-45. doi: 10.1269/jrr.36.38.

Authors

K Sato¹, D J Chen, K Eguchi-Kasai, H Itsukaichi, T Odaka, G F Strniste

Affiliation

¹ Division of Radiation Hazards, National Institute of Radiological Sciences, Chiba, Japan.

PMID: 7616486
DOI: 10.1269/jrr.36.38

Abstract

Interspecific and intraspecific hybrids were formed between mouse and Chinese hamster cell mutants hypersensitive to ionizing radiation and their radiosensitivities were examined. Chinese hamster cell mutants irs1, irs2 and irs3 and mouse mammary carcinoma cell mutants SX9 and SX10 have been found to belong to five different complementation groups. A radiosensitive mouse lymphoma cell line L5178Y-S has been demonstrated to be different from the X-ray sensitive mouse cell mutants M10 and LX830, both of which are derived from L5178Y cells, in their complementation groups. L5178Y-S is also distinct from SX9 and SX10.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Fusion
Cells, Cultured
Cricetinae
Cricetulus
Hybrid Cells
Mice
Mutation*
Radiation Effects*
Species Specificity*