Abstract
The mechanisms that regulate regional specification and evolution of the cerebral cortex are obscure. To this end, we have identified and characterized a novel murine and human gene encoding a putative transcription factor related to the Brachyury (T) gene that is expressed only in postmitotic cells. T-brain-1 (Tbr-1) mRNA is largely restricted to the cerebral cortex, where during embryogenesis it distinguishes domains that we propose may give rise to paleocortex, limbic cortex, and neocortex. Tbr-1 and Id-2 expression in the neocortex have discontinuities that define molecularly distinct neocortical areas. Tbr-1 expression is analyzed in the context of the prosomeric model. Topological maps are proposed for the organization of the dorsal telencephalon.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cerebral Cortex / physiology*
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Chromosome Mapping
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Cloning, Molecular
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DNA / genetics*
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DNA-Binding Proteins / genetics*
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Fetal Proteins / genetics*
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Gene Expression Regulation, Developmental / genetics*
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Humans
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In Situ Hybridization
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Mice
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Molecular Sequence Data
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Prosencephalon / physiology
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Sequence Analysis, DNA
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Sequence Homology, Nucleic Acid*
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T-Box Domain Proteins*
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TATA Box / genetics
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Thalamus / physiology
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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Fetal Proteins
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T-Box Domain Proteins
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Transcription Factors
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DNA
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Brachyury protein
Associated data
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GENBANK/U49250
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GENBANK/U49251