Abstract
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day-1) and pravastatin (40 mg day-1) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Anticholesteremic Agents / administration & dosage
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Anticholesteremic Agents / adverse effects*
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Anticholesteremic Agents / therapeutic use
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Cognition / drug effects*
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Cross-Over Studies
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Double-Blind Method
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Female
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Humans
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Hypercholesterolemia / drug therapy*
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Lipids / blood
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Lovastatin / administration & dosage
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Lovastatin / adverse effects
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Lovastatin / analogs & derivatives*
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Lovastatin / therapeutic use
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Male
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Middle Aged
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Pravastatin / administration & dosage
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Pravastatin / adverse effects*
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Pravastatin / therapeutic use
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Simvastatin
Substances
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Anticholesteremic Agents
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Lipids
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Lovastatin
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Simvastatin
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Pravastatin