Abstract
The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findings suggest that tumor necrosis factor alpha production may be up-regulated at both the posttranscriptional and transcriptional levels. Regulation at the posttranscriptional level probably reflects enhanced translational efficiency.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / immunology*
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Humans
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In Vitro Techniques
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Molecular Weight
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Monocytes / immunology*
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Mycobacterium tuberculosis / immunology*
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RNA, Messenger / metabolism
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Tumor Necrosis Factor-alpha / biosynthesis*
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Tumor Necrosis Factor-alpha / genetics
Substances
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Antigens, Bacterial
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RNA, Messenger
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Tumor Necrosis Factor-alpha