Two sesquiterpene quinols, cyclorenierins A [1] and B [2], which are closely related to panicein A2 [3] and renierin A [4], were isolated as an inseparable mixture from the marine sponge Haliclona sp. collected in Vanuatu. Structures were proposed using nmr shift analogies to 3 and 4 and confirmed with 2D nmr data.