Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies

Leukemia. 1995 Jul;9(7):1162-6.

Abstract

We report on three patients with acute non-lymphoblastic leukemia (ANLL) displaying the same chromosomal translocation t(11;15)(q23;q14). The clinical course of the disease was aggressive, and survival was short. The FAB subtype was M-2 in two cases, and M-1 in the remaining patient. Immunologically two cases showed aberrant expression of a lymphoid antigen (CD19 and TdT, respectively). HTRX1/MLL gene was rearranged in one patient studied at the time of diagnosis. These results plus data scattered in the literature show that the t(11;15)(q23;q14) can be added to the list of recurrent rearrangements in ANLL involving 11q23.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Southern
  • Child
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 15*
  • DNA-Binding Proteins / genetics
  • Gene Rearrangement
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Myeloid-Lymphoid Leukemia Protein
  • Proto-Oncogenes*
  • Transcription Factors*
  • Translocation, Genetic*

Substances

  • DNA-Binding Proteins
  • KMT2A protein, human
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase