Myosin structure/function: a combined mutagenesis-crystallography approach

Curr Opin Struct Biol. 1995 Apr;5(2):181-6. doi: 10.1016/0959-440x(95)80073-5.

Abstract

In the past year, the structure of the regulatory domain of scallop myosin has joined that of the chicken skeletal muscle myosin subfragment 1 and provided insights into the regulation of myosin function. Mutagenesis studies in a variety of systems have used the information provided by these structures to create mutant myosins to test models of chemomechanical transduction and its regulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Binding Sites
  • Calcium / metabolism
  • Crystallography, X-Ray
  • Models, Molecular
  • Mutagenesis
  • Myosins / chemistry*
  • Myosins / physiology*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary

Substances

  • Adenosine Triphosphate
  • Myosins
  • Calcium