Effect of an ACTH(4-9) analogue on cisplatin neuropathy of longstanding duration: a phase II study

P H Hilkens; M E van der Burg; J W Moll; M J van den Bent; W L van Putten; C J Vecht

doi:10.1016/0303-8467(95)00023-d

Effect of an ACTH(4-9) analogue on cisplatin neuropathy of longstanding duration: a phase II study

Clin Neurol Neurosurg. 1995 May;97(2):139-41. doi: 10.1016/0303-8467(95)00023-d.

Authors

P H Hilkens¹, M E van der Burg, J W Moll, M J van den Bent, W L van Putten, C J Vecht

Affiliation

¹ Department of Neuro-Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital, Rotterdam, Netherlands.

PMID: 7656487
DOI: 10.1016/0303-8467(95)00023-d

Abstract

The efficacy of Org 2766, an ACTH(4-9) analogue, on the recovery of cisplatin neuropathy of longstanding duration was investigated in a phase II study. Twenty-two patients were treated with Org 2766 during a period of 4 months and vibration perception threshold (VPT) and sum scores for neuropathic symptoms and signs were compared with pre-treatment values. No change in VPT could be detected. Although there was a small improvement of clinical measures for neuropathy, no clear evidence for repair could be obtained. These results indicate no beneficial effect of Org 2766 on recovery of a longstanding cisplatin neuropathy.

Publication types

Comparative Study

MeSH terms

Adrenocorticotropic Hormone / administration & dosage
Adrenocorticotropic Hormone / analogs & derivatives*
Adrenocorticotropic Hormone / therapeutic use
Adult
Aged
Anticonvulsants*
Brain Diseases / drug therapy*
Brain Diseases / etiology*
Brain Diseases / physiopathology
Cisplatin / administration & dosage
Cisplatin / adverse effects*
Cisplatin / therapeutic use*
Female
Humans
Male
Middle Aged
Motion Perception
Neoplasms / drug therapy*
Peptide Fragments / administration & dosage
Peptide Fragments / therapeutic use*
Prospective Studies
Treatment Outcome
Vibration

Substances

Anticonvulsants
Peptide Fragments
Org 2766
Adrenocorticotropic Hormone
Cisplatin