A new anti-reflux procedure, cardiac oblique invagination, was designed. Having succeeded in animal experiment, we performed this procedure clinically. Sixteen patients with sliding hiatus hernia and one with paraesophageal hernia were operated on. Reflux symptoms disappeared postoperatively. Esophageal manometric study showed that the pressure of HPZ elevated and no abnormal reflux was found by 24-hour esophageal pH monitoring. The effectiveness of this method was assumed that the abdominal segment of the esophagus, His angle, and cardiac rosette were well established and, also, this procedure fitted in with LaPlace's law. The method was simple, transabdominal, easy to teach, and it provided excellent short-term result.