Ceramide: an endogenous regulator of apoptosis and growth suppression

Immunol Today. 1995 Jun;16(6):294-7. doi: 10.1016/0167-5699(95)80184-7.

Abstract

The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentiation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Cell Cycle / drug effects
  • Cell Cycle / physiology
  • Cell Differentiation / drug effects
  • Ceramides / pharmacology
  • Ceramides / physiology*
  • Cytokines / physiology
  • Diglycerides / physiology
  • Gene Expression Regulation / drug effects
  • Growth Inhibitors / pharmacology
  • Growth Inhibitors / physiology*
  • Humans
  • Phosphorylation / drug effects
  • Protein Processing, Post-Translational / drug effects
  • Protein Processing, Post-Translational / physiology
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Sphingomyelins / physiology
  • Stress, Physiological / physiopathology
  • Transcription Factors / physiology
  • Tumor Cells, Cultured / drug effects

Substances

  • 1,2-diacylglycerol
  • Ceramides
  • Cytokines
  • Diglycerides
  • Growth Inhibitors
  • Sphingomyelins
  • Transcription Factors