Aplysillin A, a thrombin receptor antagonist from the marine sponge Aplysina fistularis fulva

N K Gulavita; S A Pomponi; A E Wright; M Garay; M A Sills

doi:10.1021/np50120a023

Aplysillin A, a thrombin receptor antagonist from the marine sponge Aplysina fistularis fulva

J Nat Prod. 1995 Jun;58(6):954-7. doi: 10.1021/np50120a023.

Authors

N K Gulavita¹, S A Pomponi, A E Wright, M Garay, M A Sills

Affiliation

¹ Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946, USA.

PMID: 7673943
DOI: 10.1021/np50120a023

Abstract

Aplysillin A [1], an unusual disulfate ester of a 1,4-diphenyl-1,3-butadiene, was isolated from a deep water specimen of a sponge of the genus Aplysina. Its structure was determined through spectroscopic methods. The compound weakly inhibited binding to the thrombin receptor with an IC50 value of 20 microM.

MeSH terms

Animals
Blood Platelets / drug effects
Blood Platelets / metabolism
Cell Membrane / drug effects
Cell Membrane / metabolism
Humans
In Vitro Techniques
Iodine Radioisotopes
Magnetic Resonance Spectroscopy
Methylation
Phenols / isolation & purification*
Phenols / pharmacology
Porifera / chemistry*
Receptors, Thrombin / antagonists & inhibitors*
Sulfuric Acid Esters / isolation & purification*
Sulfuric Acid Esters / pharmacology

Substances

Iodine Radioisotopes
Phenols
Receptors, Thrombin
Sulfuric Acid Esters
aplysillin A