Clonal fibroblastic cell lines established from a heavily exposed atomic bomb survivor

Mutat Res. 1993 Apr;291(2):125-33. doi: 10.1016/0165-1161(93)90151-o.

Abstract

Two clonal fibroblast cell lines with simple chromosome aberrations-one with del(3)(p24) and the other with t(1;16)(q21;q11.2)-were established from a high dose (5.14 Gy) female atomic bomb survivor by serial culture of skin fibroblasts. These two types of clonal cells showed a more extended life span than did the cells with 44 other types of chromosome aberrations and normal cells. In addition to these results, a prominent clonal population was observed in the peripheral blood cells in this subject. It is assumed that these clonal populations arose in vivo as a result of radiation exposure to the atomic bomb.

MeSH terms

  • Aged
  • Apoptosis / radiation effects*
  • Cell Division / radiation effects
  • Cell Line
  • Chromosome Aberrations*
  • Chromosome Banding
  • Chromosome Deletion
  • Chromosomes, Human, Pair 1
  • Chromosomes, Human, Pair 16
  • Chromosomes, Human, Pair 3
  • Clone Cells
  • Dose-Response Relationship, Radiation
  • Female
  • Fibroblasts / radiation effects*
  • Humans
  • Japan
  • Karyotyping
  • Lymphocytes / radiation effects
  • Nuclear Warfare*
  • Skin / cytology
  • Translocation, Genetic