Abstract
The analysis of a series of monoclonal antibodies (mAbs) developed in our laboratory against gut-associated antigens of Schistosoma mansoni is described. It was found that mAbs that recognized epitopes of antigens in the gut and on the eggshell were mainly of the IgM isotype; these epitopes are likely to be carbohydrate in composition. Of a number of mAbs that were reactive with antigens important to the human humoral immune response, 75% appeared to be reactive with the circulating cathodic antigen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Helminth / blood
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Antibodies, Helminth / immunology*
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Antibodies, Monoclonal / immunology
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Antibody Specificity
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Antigens, Helminth / immunology*
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Antigens, Helminth / isolation & purification
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Cricetinae
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Epitopes
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Fluorescent Antibody Technique
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Humans
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Immunoglobulin G / immunology
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Immunoglobulin M / immunology
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Intestines / immunology*
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Male
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Mesocricetus / parasitology
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Ovum / immunology*
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Schistosoma mansoni / immunology*
Substances
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Antibodies, Helminth
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Antibodies, Monoclonal
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Antigens, Helminth
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Epitopes
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Immunoglobulin G
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Immunoglobulin M