Acute myeloid leukemia with concomitant expression of T-/B-lymphoid antigens and immunogenotypic alterations exhibiting t(7;12)(q32;q24)

K Kawakubo; K Ohyashiki; J H Ohyashiki; Y Kuriyama; A Iwabuchi; N Kimura; K Sugita; S Nakazawa; K Toyama

Acute myeloid leukemia with concomitant expression of T-/B-lymphoid antigens and immunogenotypic alterations exhibiting t(7;12)(q32;q24)

Leukemia. 1993 Jun;7(6):909-11.

Authors

K Kawakubo¹, K Ohyashiki, J H Ohyashiki, Y Kuriyama, A Iwabuchi, N Kimura, K Sugita, S Nakazawa, K Toyama

Affiliation

¹ First Department of Internal Medicine, Tokyo Medical College, Japan.

PMID: 7684801

Abstract

We report here a patient with acute myeloid leukemia (AML) expressing both T- and B-lymphoid-associated antigens. The leukemia cells in this case had rearrangements of not only immunoglobulin heavy-chain but also T-cell-receptor beta- and delta-chain genes. Although a relatively large number of AML patients with lymphoid markers have been reported, only about a dozen AML patients expressing both T- and B-lymphoid markers have been reported so far.

Publication types

Case Reports

MeSH terms

Antigens, CD / genetics
Antigens, CD19
Antigens, Differentiation, B-Lymphocyte / analysis
Antigens, Differentiation, B-Lymphocyte / genetics
Antigens, Differentiation, T-Lymphocyte / analysis
B-Lymphocytes / immunology*
CD2 Antigens
Chromosome Banding
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 7
Female
Genes, Immunoglobulin
Humans
Immunophenotyping
Leukemia, Myeloid, Acute / immunology*
Middle Aged
Receptors, Antigen, T-Cell, alpha-beta / genetics
Receptors, Antigen, T-Cell, gamma-delta / genetics
Receptors, Immunologic / analysis
T-Lymphocytes / immunology*
Translocation, Genetic

Substances

Antigens, CD
Antigens, CD19
Antigens, Differentiation, B-Lymphocyte
Antigens, Differentiation, T-Lymphocyte
CD2 Antigens
Receptors, Antigen, T-Cell, alpha-beta
Receptors, Antigen, T-Cell, gamma-delta
Receptors, Immunologic