Abstract
Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antibody Formation*
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Antigens, CD / physiology*
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Antigens, Differentiation, B-Lymphocyte / physiology*
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B-Lymphocyte Subsets / cytology*
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B-Lymphocyte Subsets / immunology
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B-Lymphocyte Subsets / metabolism
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CD40 Antigens
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CD40 Ligand
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Cell Adhesion
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Cell Differentiation
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Cricetinae
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Humans
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Lymphocyte Activation / physiology*
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Lymphocyte Cooperation*
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Lymphokines / physiology
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Membrane Glycoproteins / physiology*
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Mice
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Models, Biological
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Signal Transduction
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T-Lymphocytes, Helper-Inducer / immunology
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD40 Antigens
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Lymphokines
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Membrane Glycoproteins
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CD40 Ligand