Abstract
1. Trypanosoma brucei brucei-infected mouse models treated with a new antibiotic, reuterin, showed reduction of the levels of parasitemia and prolonged survival of the mice. 2. Cures of the parasitemia were observed in groups of mice treated with combinations of reuterin and suramin or melarsoprol. 3. Reuterin administered in combination with bleomycin or DL-alpha-difluoromethylornithine showed temporary remission of the parasitemia in groups of mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Anti-Bacterial Agents / toxicity
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Bleomycin / administration & dosage
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Bleomycin / therapeutic use
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Bleomycin / toxicity
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Drug Therapy, Combination
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Eflornithine / administration & dosage
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Eflornithine / therapeutic use
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Eflornithine / toxicity
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Female
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Glyceraldehyde / analogs & derivatives
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Lethal Dose 50
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Melarsoprol / administration & dosage
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Melarsoprol / therapeutic use
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Melarsoprol / toxicity
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Mice
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Propane
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Suramin / administration & dosage
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Suramin / therapeutic use
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Suramin / toxicity
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Trypanosomiasis, African / drug therapy*
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Trypanosomiasis, African / parasitology
Substances
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Aldehydes
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Anti-Bacterial Agents
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Bleomycin
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3-hydroxypropionaldehyde
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Glyceraldehyde
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Suramin
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Propane
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Melarsoprol
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Eflornithine