Abstract
In the isolated perfused guinea pig heart coronary occlusion lasting 1-5 s is followed by reactive hyperaemia which is inhibited by 91-100% after pretreatment with a NO synthase inhibitor, NG-nitro-L-arginine (100 microM). Neither indomethacin (5 microM) nor 8-phenyltheophylline (10 microM) influences these responses. Therefore, the brief cardiac reactive hyperaemia seems to be predominantly if not entirely mediated by nitric oxide (NO).
MeSH terms
-
Acetylcholine / pharmacology
-
Amino Acid Oxidoreductases / antagonists & inhibitors
-
Animals
-
Arginine / analogs & derivatives
-
Arginine / pharmacology
-
Blood Pressure / drug effects
-
Coronary Vessels / physiology*
-
Female
-
Guinea Pigs
-
Hyperemia / physiopathology*
-
In Vitro Techniques
-
Indomethacin / pharmacology
-
Male
-
Nitric Oxide / physiology*
-
Nitric Oxide Synthase
-
Nitroarginine
-
Theophylline / analogs & derivatives
-
Theophylline / pharmacology
-
Ventricular Function, Left / drug effects
-
Ventricular Pressure / drug effects
Substances
-
Nitroarginine
-
Nitric Oxide
-
Arginine
-
Theophylline
-
8-phenyltheophylline
-
Nitric Oxide Synthase
-
Amino Acid Oxidoreductases
-
Acetylcholine
-
Indomethacin