Characterization of a unique retroviral recombinant containing 7S L sequences

J Virol. 1993 Dec;67(12):7677-9. doi: 10.1128/JVI.67.12.7677-7679.1993.

Abstract

Using a recently described system to generate recombinants between avian leukosis viruses (ALV) and cellular neo mRNA (A.M. Hajjar and M.L. Linial, J. Virol. 67:3845-3853, 1993), we isolated a recombinant containing 7S L sequences. Analysis of this recombinant revealed that it most likely arose during reverse transcription of three copackaged RNAs: 7S L RNA, neo RNA, and ALV genomic RNA. Reverse transcription appears to have initiated on the 7S L RNA. A model for the generation of this recombinant is described.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avian Leukosis Virus / genetics*
  • Base Sequence
  • Humans
  • Models, Genetic
  • Molecular Sequence Data
  • Quail
  • RNA / genetics*
  • RNA, Viral / genetics*
  • Recombination, Genetic*
  • Transcription, Genetic*

Substances

  • RNA, Viral
  • RNA, recombinant
  • RNA