Abstract
In a randomized trial, a three-dose quinine monotherapy was compared with short-term combination regimens of quinine-clindamycin and quinine-doxycycline for treating adult Gabonese patients with Plasmodium falciparum malaria. In quinine-treated patients, only 38% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Clindamycin / administration & dosage*
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Doxycycline / administration & dosage*
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Drug Administration Schedule
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Drug Therapy, Combination
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Gabon
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Humans
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Malaria, Falciparum / drug therapy*
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Male
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Middle Aged
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Quinine / administration & dosage*
Substances
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Clindamycin
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Quinine
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Doxycycline