With the exception of the simple Luer or Spike type systems all of the presently used CAPD devices have a system for intraluminal sterilization and/or an handling assist device. The sterilizing process can be chemical (antiseptics), physical (heat or ultraviolet (UV) light) or mechanical (flush effect). Studies comparing various peritoneal dialysis devices have led to results which diverge greatly, and are not always controlled. Synthesis of these studies shown that disconnect systems (DS) seemed to be not more effective against bacteriological contamination than the last generations of UV non-disconnect (NDS) systems. Efficacy of heat sterilization NDS must be confirmed. The choice of a NDS does not result only from a medical indication.