Abstract
A polymorphic CA repeat (locus name DXS1178) was isolated from a 1-megabase YAC (OTCC) containing the OTC gene, located at Xp21.1. However, amplification in human-rodent hybrid cells and segregation analysis in three CEPH families mapped the DXS1178 locus at Xq13. The mapping ambiguity is apparently caused by the chimeric nature of the OTCC YAC clone.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Animals
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Base Sequence
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Chromosome Mapping
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Chromosomes, Artificial, Yeast
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DNA Primers / chemistry
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Humans
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Mice
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Molecular Sequence Data
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Ornithine Carbamoyltransferase / genetics
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Phosphoglycerate Kinase / genetics*
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Repetitive Sequences, Nucleic Acid / genetics*
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Retinitis Pigmentosa / genetics
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X Chromosome*
Substances
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DNA Primers
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Ornithine Carbamoyltransferase
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Phosphoglycerate Kinase