New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. VII. Structure determination of brominated lachnumon and mycorrhizin A derivatives

M Stadler; H Anke; O Sterner

doi:10.7164/antibiotics.48.158

New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. VII. Structure determination of brominated lachnumon and mycorrhizin A derivatives

J Antibiot (Tokyo). 1995 Feb;48(2):158-61. doi: 10.7164/antibiotics.48.158.

Authors

M Stadler¹, H Anke, O Sterner

Affiliation

¹ University of Kaiserslautern, Department of Biotechnology, Germany.

PMID: 7706127
DOI: 10.7164/antibiotics.48.158

Abstract

The structure determination of lachnumon B1 (16) and lachnumon B2 (17), brominated derivatives of lachnumon (1), as well as mycorrhizin B1 (18) and mycorrhizin B2 (19), brominated derivatives of mycorrhizin A (3), is described. The compounds, which exhibit similar antimicrobial and nematicidal activity as their chlorinated analogues, were isolated from extracts of cultures of the ascomycete Lachnum papyraceum to which CaBr2 had been added. The structures were elucidated by spectroscopic methods.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Antinematodal Agents / chemistry*
Antinematodal Agents / pharmacology
Ascomycota / metabolism*
Bromine / chemistry*
Coumarins / chemistry*
Cyclohexanones / chemistry*
Epoxy Compounds / chemistry*
Magnetic Resonance Spectroscopy
Mass Spectrometry / methods
Molecular Structure

Substances

Anti-Bacterial Agents
Antinematodal Agents
Coumarins
Cyclohexanones
Epoxy Compounds
lachnumon
mycorrhizin A
Bromine