Treatment of progressive outer retinal necrosis with sorivudine

Am J Ophthalmol. 1995 Apr;119(4):516-7. doi: 10.1016/s0002-9394(14)71242-5.

Abstract

Purpose/methods: We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome.

Results/conclusions: The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine. Treatment for progressive outer retinal necrosis has been disappointing; both acyclovir and ganciclovir have had only limited success. Sorivudine, a new antiviral medication with activity against varicella-zoster virus, may represent an effective alternative treatment for retinal necrosis.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Arabinofuranosyluracil / administration & dosage
  • Arabinofuranosyluracil / analogs & derivatives*
  • Arabinofuranosyluracil / therapeutic use
  • Drug Therapy, Combination
  • Ganciclovir / administration & dosage
  • Ganciclovir / therapeutic use
  • Herpes Zoster Ophthalmicus / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Retinal Necrosis Syndrome, Acute / drug therapy*
  • Retinal Necrosis Syndrome, Acute / virology

Substances

  • Antiviral Agents
  • Arabinofuranosyluracil
  • sorivudine
  • Ganciclovir