Since results of conventional FFT-power-analysis are reference-dependent, only unambiguous neurophysiological data should be used for a functional physiological interpretation of EEG-data. FFT-approximation with successive center-of-gravity-dipole calculation gives unambiguous EEG-data with regard to recording reference. In the present investigation 22 medicated schizophrenic patients were compared with 22 healthy age- and sex-matched controls with regard to spontaneous resting EEG. More anterior and superficial equivalent-dipoles were found in the beta-bands for schizophrenic patients compared to healthy control subjects. There was a tendency of increased beta-activity in schizophrenic subjects. With more severe schizophrenic symptoms (higher BPRS-score), the more anterior was the equivalent-dipole localization in the beta 1-band, and the deeper in the theta-band. The different locations of the beta-band dipoles in schizophrenic patients suggest that different neuronal populations generate beta-activity in schizophrenia compared to healthy controls. FFT-approximation allows a substantial and meaningful data reduction in multichannel recordings and will hopefully help in understanding pathological brain functions in schizophrenia.