108 cases of advanced non-small cell lung cancer (NSCLC) with Qi deficiency and blood stasis syndrome (QDBS) had been studied in this paper. It has been found that: (1) QDBS existed commonly in 60.2% of NSCLC patients. (2) QDBS patients had lowered immune function and blood hypercoagulating function, as compared with healthy persons. (3) The abnormal change of immunological indexes such as TC subgroup. TXB2, 6-keto-PGF1 alpha, fibrinogen and plasmin activity as well as hemorheological indices are important pathophysiological manifestation of QDBS. Thus, the principle of supplementing Qi and activating blood circulation combined with reducing phlegm and resolving masses should be emphasized in future research.