Abstract
We have found by 'in situ' hybridization a high level of expression of insulin- like growth factor I receptor (IGF-I R) gene in foam cells of atherosclerotic rabbit aortas. By reaction with either anti- rabbit macrophage (RAM11) or anti smooth muscle cell antibodies we also found that most cells expressing increased amounts of IGF-I R mRNA were of smooth muscle cell origin. Thus, increased IGF-I R mRNA levels might be related to the genesis of the atheroma plaque.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta / metabolism
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Aorta / ultrastructure
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Arteriosclerosis / metabolism*
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Arteriosclerosis / pathology
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Female
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In Situ Hybridization
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Microscopy, Electron
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Muscle, Smooth, Vascular / metabolism
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Muscle, Smooth, Vascular / ultrastructure
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RNA, Messenger / biosynthesis*
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RNA, Messenger / genetics
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Rabbits
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Receptors, Somatomedin / biosynthesis*
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Receptors, Somatomedin / genetics
Substances
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RNA, Messenger
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Receptors, Somatomedin