Abstract
The recently reported crystal structures of two recombination enzymes, the catalytic domain of HIV integrase and Escherichia coli RuvC, an endonuclease, are surprisingly similar to that of ribonuclease H suggesting the possibility that they have a common enzymatic mechanism.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bacterial Proteins / chemistry*
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DNA Nucleotidyltransferases / chemistry*
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Endodeoxyribonucleases / chemistry*
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Escherichia coli / enzymology
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Escherichia coli Proteins*
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HIV / enzymology*
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Humans
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Integrases
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Protein Structure, Secondary*
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Recombination, Genetic / genetics
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Ribonuclease H / chemistry*
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Virus Integration / physiology*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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ruvC protein, E coli
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DNA Nucleotidyltransferases
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Integrases
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Endodeoxyribonucleases
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Ribonuclease H