A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment

J C Cigudosa; M J Calasanz; M D Odero; J Marín; E Bengoechea; A Gullón

doi:10.1016/0165-4608(94)00182-b

A variant t(14;17) in acute promyelocytic leukemia. Positive response to retinoic acid treatment

Cancer Genet Cytogenet. 1995 Apr;80(2):160-1. doi: 10.1016/0165-4608(94)00182-b.

Authors

J C Cigudosa¹, M J Calasanz, M D Odero, J Marín, E Bengoechea, A Gullón

Affiliation

¹ Department of Genetics, University of Navarra, Pamplona, Spain.

PMID: 7736436
DOI: 10.1016/0165-4608(94)00182-b

Abstract

We present a case of acute promyelocytic leukemia (APL) carrying an atypical translocation involving chromosomes 14 and 17. This translocation could be considered a variant of the APL-specific t(15;17). Positive response to retinoic acid treatment suggests molecular rearrangement of retinoic acid receptor alpha.

Publication types

Case Reports

MeSH terms

Adult
Bone Marrow Transplantation
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 17*
Combined Modality Therapy
Humans
Karyotyping
Leukemia, Promyelocytic, Acute / drug therapy
Leukemia, Promyelocytic, Acute / genetics*
Leukemia, Promyelocytic, Acute / therapy
Male
Remission Induction
Translocation, Genetic*
Tretinoin / therapeutic use*

Substances

Tretinoin