Abstract
A cordycepin-resistant mutant strain of Saccharomyces cerevisiae (CD-R2) was found to be deficient in adenosine kinase. This mutant accumulated S-adenosylhomocysteine during growth in the presence of exogenous adenosine and it grew in a pseudohyphal manner in the presence of this nucleotide.
MeSH terms
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Adenosine / metabolism
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Adenosine Kinase / genetics*
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Biotransformation
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Cell Division / drug effects
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Deoxyadenosines / pharmacokinetics
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Deoxyadenosines / pharmacology
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Drug Resistance, Microbial / genetics
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Mutation*
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S-Adenosylhomocysteine / metabolism
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae / genetics*
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Thiamine / pharmacology
Substances
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Deoxyadenosines
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S-Adenosylhomocysteine
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Adenosine Kinase
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cordycepin
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Adenosine
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Thiamine