A new material with theoretical osteoinductive properties: experimental evaluation

Boll Soc Ital Biol Sper. 1994 Dec;70(12):315-22.

Abstract

An intensive research for bone substitutes has been in progress for several decades in order to find a new ideal material for bone replacement. In the present study the Authors report some data on a new developed material in comparison with synthetic hydroxyapatite. The new material was characterised by means of a crystallographic spectroscopic and chemical study. An in vitro test was also performed using murine fibroblasts. The results of this preliminary study showed that the sintered material has an and beta-tricalcium-phosphate (TCP) lattice depending on thermal treatment in accordance with literature data. Moreover, it showed a high level of biocompatibility. Though it is still in an investigation stage, perhaps this biomaterial is a highly reactive and unstable compound that could interact with CO2 and H2O.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / toxicity
  • Bone Remodeling / drug effects
  • Calcium Phosphates / chemistry
  • Cell Line
  • Crystallography, X-Ray
  • Durapatite / chemistry
  • Fibroblasts / drug effects
  • Hot Temperature
  • L-Lactate Dehydrogenase / analysis
  • Mice
  • Spectrophotometry, Infrared

Substances

  • Biocompatible Materials
  • Calcium Phosphates
  • alpha-tricalcium phosphate
  • tetracalcium phosphate
  • calcium phosphate, monobasic, anhydrous
  • Durapatite
  • calcium phosphate
  • L-Lactate Dehydrogenase
  • calcium phosphate, dibasic, anhydrous