Abstract
A new toxic sesterterpene, named fusaproliferin, was purified from corn kernel cultures (120 mg/kg dry culture) of a strain of Fusarium proliferatum isolated from corn ear rot in northern Italy. The stain, designated ITEM-1494, also produced fumonisin B1 (1.500 mg/kg dry culture) and beauvericin (90 mg/kg dry culture), but not moniliformin. To monitor toxicity, the brine shrimp assay was used throughout the isolation procedure. Fusaproliferin had a molecular formula of C27H40O5, and it is the first sesterterpene isolated from a Fusarium species.
MeSH terms
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Animals
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Anti-Bacterial Agents / analysis
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Anti-Bacterial Agents / isolation & purification
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Artemia / physiology
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Carcinogens, Environmental / analysis
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Carcinogens, Environmental / isolation & purification
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Culture Media
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Cyclobutanes / analysis
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Cyclobutanes / isolation & purification
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Depsipeptides*
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Fumonisins*
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Fusarium / metabolism*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mycotoxins / analysis
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Mycotoxins / isolation & purification*
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Peptides*
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Terpenes / analysis
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Terpenes / isolation & purification*
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Zea mays
Substances
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Anti-Bacterial Agents
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Carcinogens, Environmental
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Culture Media
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Cyclobutanes
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Depsipeptides
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Fumonisins
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Mycotoxins
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Peptides
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Terpenes
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fusaproliferin
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beauvericin
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moniliformin
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fumonisin B1