Neosiphoniamolide A, a novel cyclodepsipeptide, with antifungal activity from the marine sponge Neosiphonia superstes

M V D'Auria; L Gomez Paloma; L Minale; A Zampella; C Debitus; J Perez

doi:10.1021/np50115a017

Neosiphoniamolide A, a novel cyclodepsipeptide, with antifungal activity from the marine sponge Neosiphonia superstes

J Nat Prod. 1995 Jan;58(1):121-3. doi: 10.1021/np50115a017.

Authors

M V D'Auria¹, L Gomez Paloma, L Minale, A Zampella, C Debitus, J Perez

Affiliation

¹ Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.

PMID: 7760068
DOI: 10.1021/np50115a017

Abstract

A novel cyclodepsipeptide, neosiphoniamolide A [1], has been isolated from the sponge Neosiphonia superstes. The structure of 1, which contains a 12-carbon hydroxy acid, glycine, valine, and a halogenated tyrosine residue in an 18-membered ring, is related to jaspamide and the geodiamolides, previously isolated from sponges. The structure was solved by spectroscopic analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Peptides, Cyclic / chemistry
Peptides, Cyclic / isolation & purification*
Peptides, Cyclic / pharmacology
Porifera / chemistry*

Substances

Antifungal Agents
Peptides, Cyclic
neosiphoniamolide A