Abstract
We have noninvasively detected the proton signal of an antineoplastic agent Iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Without isotopic labeling or chemical modification, the Sel-MQC method labels Iproplatin by its intrinsic proton multiple quantum coherences and, hence, differentiates the Iproplatin signal from the intensive overlapping resonances of lipid and lactate. This proton NMR method should also be applicable to study other drugs with appropriate spin coupling patterns.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / metabolism*
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Body Water / metabolism
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Fibrosarcoma / metabolism*
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Half-Life
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Hydrogen
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Injections, Intraperitoneal
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Lactates / metabolism
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Lipid Metabolism
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Magnetic Resonance Spectroscopy* / methods
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Mice
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Mice, Inbred C3H
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Mice, Inbred Strains
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Neoplasm Transplantation
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / metabolism*
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Soft Tissue Neoplasms / metabolism*
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Spin Labels
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Lactates
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Organoplatinum Compounds
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Spin Labels
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iproplatin
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Hydrogen