Changes in stiffness induced by hindlimb suspension in rat soleus muscle

Pflugers Arch. 1995 Jan;429(3):332-7. doi: 10.1007/BF00374147.

Abstract

Soleus muscle atrophy was induced by hind-limb suspension of rats for 3 weeks with the intention of inducing a relative increase in the percentage of fast-twitch fibres and assessing modifications in muscle stiffness. A method of dual controlled releases was used to obtain tension/extension curves and force/velocity relationships characterizing the mechanical behaviour of the soleus. Fibre typing was achieved by myofibrillar adenosine 5'-triphosphatase staining. Results showed that hindlimb suspension decreased the percentage of slow-twitch fibres (-31%) to the profit of fast-twitch fibres (+370%) and intermediate fibres (+255%). This led to an increase in maximal shortening velocity. Tension/extension curves indicated a decrease in soleus stiffness after 3 weeks of unloading. Changes in elastic properties are interpreted in terms of modifications occurring in the active part and the passive part of the so-called series elastic component. These changes also suggest that the parameters derived from a twitch are inappropriate to account for modifications in speed-related properties of muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / physiology
  • Animals
  • Body Weight / physiology
  • Hindlimb / physiology*
  • Histocytochemistry
  • Male
  • Muscle Contraction / physiology
  • Muscle Fibers, Fast-Twitch / physiology
  • Muscle, Skeletal / physiology*
  • Organ Size / physiology
  • Rats
  • Rats, Wistar
  • Weightlessness Simulation*