Abstract
Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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Bacillus subtilis / drug effects
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Carbohydrate Sequence
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Glycosides / chemical synthesis
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Glycosides / chemistry*
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Glycosides / pharmacology
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Glycyrrhetinic Acid / chemistry*
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Glycyrrhetinic Acid / pharmacology
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Molecular Sequence Data
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Staphylococcus aureus / drug effects
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Structure-Activity Relationship
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Trichophyton / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Glycosides
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Glycyrrhetinic Acid