Cytotoxic clerodane diterpenes from Polyalthia barnesii

X Ma; I S Lee; H B Chai; K Zaw; N R Farnsworth; D D Soejarto; G A Cordell; J M Pezzuto; A D Kinghorn

doi:10.1016/s0031-9422(00)89587-4

Cytotoxic clerodane diterpenes from Polyalthia barnesii

Phytochemistry. 1994 Dec;37(6):1659-62. doi: 10.1016/s0031-9422(00)89587-4.

Authors

X Ma¹, I S Lee, H B Chai, K Zaw, N R Farnsworth, D D Soejarto, G A Cordell, J M Pezzuto, A D Kinghorn

Affiliation

¹ Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.

PMID: 7766002
DOI: 10.1016/s0031-9422(00)89587-4

Abstract

Three cytotoxic clerodane diterpenes were purified from an ethyl acetate-soluble extract of the stem bark of Polyalthia barnesii, namely, 16 alpha-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a known compound, and two novel compounds, 3 beta, 16 alpha-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide and 4 beta, 16 alpha-dihydroxyclerod-13(14)Z-en-15,16-olide. These compounds were found to exhibit broad cytotoxicity against a panel of human cancer cell lines.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Humans
Molecular Structure
Spectrum Analysis
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Diterpenes

Grants and funding

U01-CA-52956/CA/NCI NIH HHS/United States