With fluorimetry, the concentration of malondialdehyde (MDA) and the ratio of MDA before and after the blood platelets activated (MDA/MDAa) were determined in patients with retinitis pigmentosa (RP). The results showed the above two parameters were statistically higher than those of the normal controls, which indicated the superoxidation metabolism increased and the blood was in a state of hypercoagulation in RP patients. The reasons for the results and their roles in RP disease were discussed. Treatments with anti-lipid, and anti-coagulation drugs combined with Chinese medicines were suggested.