Abstract
The q21 region of chromosome 17 contains the gene BRCA1, which is involved in familial early-onset breast and ovarian cancers. A physical map of a region that extends from a distal boundary of the BRCA1 region, D17S78, to GP2B has been constructed. The map consists of 30 STSs, including 2 new short tandem repeat polymorphic markers. The contig is composed of a mixture of 7 YACs, 5 P1 plasmids, and 14 cosmids and was ordered by STS-content mapping.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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BRCA1 Protein
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Base Sequence
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Breast Neoplasms / genetics
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Chromosome Mapping
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Chromosomes, Artificial, Yeast
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Chromosomes, Human, Pair 17*
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Cloning, Molecular
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Cosmids
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DNA Primers
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Genetic Markers
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Humans
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Molecular Sequence Data
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Neoplasm Proteins / genetics*
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Plasmids
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Polymerase Chain Reaction
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Transcription Factors / genetics*
Substances
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BRCA1 Protein
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DNA Primers
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Genetic Markers
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Neoplasm Proteins
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Transcription Factors