Increased susceptibility of angiographically smooth left anterior descending coronary artery to an impairment of vasoresponse to acetylcholine, and the relation between impaired vasoresponse and low-density lipoprotein cholesterol level

T Kawashima; A Yashiro; H Nandate; E Himeno; Y Oka; T Kaku; Y Nakashima; A Kuroiwa

doi:10.1016/s0002-9149(99)80775-9

Increased susceptibility of angiographically smooth left anterior descending coronary artery to an impairment of vasoresponse to acetylcholine, and the relation between impaired vasoresponse and low-density lipoprotein cholesterol level

Am J Cardiol. 1995 Jun 15;75(17):1265-7. doi: 10.1016/s0002-9149(99)80775-9.

Authors

T Kawashima¹, A Yashiro, H Nandate, E Himeno, Y Oka, T Kaku, Y Nakashima, A Kuroiwa

Affiliation

¹ Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu.

PMID: 7778552
DOI: 10.1016/s0002-9149(99)80775-9

Abstract

In the present study, we demonstrated that the angiographically smooth LAD is more susceptible than the LC to an impairment of vasoresponse to acetylcholine, suggesting the more severe endothelial dysfunction in the LAD. We also showed that levels of LDL play a partial but important role on endothelial dysfunction.

MeSH terms

Acetylcholine / pharmacology*
Adult
Aged
Cholesterol, LDL / blood*
Coronary Angiography*
Coronary Disease / diagnostic imaging
Coronary Disease / physiopathology
Coronary Vessels / drug effects*
Coronary Vessels / physiopathology
Endothelium, Vascular / physiology
Female
Humans
Male
Middle Aged
Nitroglycerin / pharmacology
Vasoconstriction / drug effects*
Vasodilation / drug effects

Substances

Cholesterol, LDL
Nitroglycerin
Acetylcholine