Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism

Arch Toxicol Suppl. 1995:17:209-14. doi: 10.1007/978-3-642-79451-3_18.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / toxicity*
  • Animals
  • Calcium / metabolism*
  • Carmustine / pharmacology
  • Chemical and Drug Induced Liver Injury / enzymology
  • Chemical and Drug Induced Liver Injury / metabolism*
  • Cytosol / enzymology
  • Energy Metabolism / drug effects*
  • Glutathione / metabolism*
  • Glutathione Reductase / antagonists & inhibitors
  • Homeostasis / drug effects
  • Male
  • Methylcholanthrene / pharmacology
  • Oxidative Stress / drug effects*
  • Rats
  • Rats, Wistar

Substances

  • Acetaminophen
  • Methylcholanthrene
  • Glutathione Reductase
  • Glutathione
  • Calcium
  • Carmustine