Abstract
Picryl chloride-induced irritant reaction (IR) was shown to be mediated by tumor necrosis factor (TNF). Anti-TNF monoclonal antibodies, but not interleukin 1 receptor antagonist (IL-1 Ra), had a protective effect. Chlorpromazine (CPZ), an inhibitor of TNF synthesis, protected against IR and inhibited the IR-associated TNF induction in ear homogenates. Investigation of the role of polymorphonuclear leukocyte (PMN) in neutropenic mice showed that neutropenia did not prevent the development of the IR.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Chlorpromazine / pharmacology*
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Dermatitis, Irritant / etiology
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Dermatitis, Irritant / prevention & control*
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Disease Models, Animal
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Haptens / physiology*
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Interleukin 1 Receptor Antagonist Protein
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Male
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Mice
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Neutropenia / chemically induced
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Neutropenia / physiopathology
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Neutrophils / drug effects
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Neutrophils / physiology
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Picryl Chloride / toxicity
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Receptors, Interleukin-1 / antagonists & inhibitors
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Sialoglycoproteins / pharmacology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Antibodies, Monoclonal
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Haptens
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Il1rn protein, mouse
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Interleukin 1 Receptor Antagonist Protein
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Receptors, Interleukin-1
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Sialoglycoproteins
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Tumor Necrosis Factor-alpha
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Chlorpromazine
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Picryl Chloride