Corticosteroid receptor antagonists: a current perspective

Pharm World Sci. 1995 Mar 24;17(2):31-41. doi: 10.1007/BF01875052.

Abstract

This review aims to highlight a selection of antagonists for the mineralocorticoid and glucocorticoid receptors. Concepts of these receptor systems are described, as is the mechanism of action of these steroids in the brain and periphery. Examples of commonly available and newly synthesized antimineralocorticoids and antiglucocorticoids are given, together with their pharmacological profiles and, when appropriate, clinical and therapeutic applications.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / antagonists & inhibitors
  • Animals
  • Humans
  • Ligands
  • Receptors, Steroid / antagonists & inhibitors*

Substances

  • Adrenal Cortex Hormones
  • Ligands
  • Receptors, Steroid