Abstract
The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide derivatives were found to be inactive while some of the saccharin derivatives were found to be fair inhibitors of these enzymes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cathepsin G
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Cathepsins / antagonists & inhibitors*
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Humans
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Leukocyte Elastase
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Magnetic Resonance Spectroscopy
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Myeloblastin
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Pancreatic Elastase / antagonists & inhibitors*
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Phthalimides / chemical synthesis*
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Phthalimides / chemistry
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Phthalimides / pharmacology
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Saccharin / analogs & derivatives*
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Saccharin / chemical synthesis
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Saccharin / chemistry
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Saccharin / pharmacology
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Serine Endopeptidases / drug effects*
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Structure-Activity Relationship
Substances
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Phthalimides
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Cathepsins
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Serine Endopeptidases
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CTSG protein, human
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Cathepsin G
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Pancreatic Elastase
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Leukocyte Elastase
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Myeloblastin
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Saccharin